LMC | Manna Research Capabilities Include:

• 19 sites across 4 provinces with 20+ years research experience as operations started in 1996
• >1600 clinical trials conducted
• Comprehensive patient database – >500,000 patients with addition of 50,000 new patients per year

• Access to a network of 80 Family Physicians & 75 Specialists with focus in Endocrine Disorders
• Phase I – 12 bed clinical pharmacology unit in Greater Toronto Area (4th largest city in North America)
• Voted one of Canada’s Best Work Places in 2014 & 2015

• Consistent leaders in Canadian & Global enrollment
• Able to work with central Ethics Review Boards

PHASE I

• 12 Metabolic Beds
• Glucose Clamping
• Metabolic Kitchen
• Access to Primary Care Patients

PHASE II – III

• 19 Sites Across Canada
• 50 Endocrinologists
• Access to 80 GP’s and 75 Specialists with focus in Endocrine Disorders
• Canada’s Largest Diabetes & Obesity Patient Registries
• Comprehensive patient database – >500,000 patients with addition of 50,000 new patients per year

PHASE IV

• Post- Marketing Analysis
• Registry Analysis
• Compliance Programs

Centralized Research Network

• SOPs / uniform source throughout all 18 sites
• CTA / Budget – 5 day average
• Regulatory – Start Up Specialists
• Recruitment / Marketing Team
• QA / QC / Training

Turn-key Services – Partnerships in place to provide:

• Regulatory Affairs
• Clinical Data Management
• Protocol & Clinical Report Writers
• Independent Clinical Research Associates
• Local Laboratory – Safety & Bioanalytical

Membership & Distinctions

• Part of Sanofi’s “Diabetes Centers of Excellence” Network
• Canadian Association of Independent Clinical Research (CAICR) Membership
• Society for Clinical Research Sites (SCRS) Membership
• PharmaTimes Clinical Research Coordinator of the Year 2017 (CROY 2017)
• Site Patient Recruitment Innovation Award (SPRIA) 2017 Winner

LMC | Manna Research Highlights

• Efficient Start Up – 33 First patient visit (FPFV) entered into trial for Canada since 2013,with 13 FPFV in 2016 alone
• >4000 patient randomizations since 2013 across all sites in Canada
• Global leaders in enrollment – possibility of using one network to enroll entire country patient allocation
• Internal Quality Assurance & Quality Control Program – Successful FDA, Health Canada & Sponsor audits
• Benefits of research in Canada: high quality, speed (30 day regulatory approval), & value (due to exchange rate)